Analytical modeling of single electron transistor for hybrid CMOS-SET analog IC design

A physically based compact analytical single electron transistor (SET) model is proposed for hybrid CMOS-SET analog circuit simulation. The modeling approach is based on the "orthodox theory" of single electron tunneling, and valid for single or multi gate, symmetric or asymmetric devices and can also explain the background charge effect. The model parameters are physical device parameters and an associated parameter extraction procedure is reported. The device characteristics produced by the proposed model are verified with Monte Carlo simulation for large range of drain to source voltages (|V/sub DS/|/spl les/3e/C/sub /spl Sigma//) and temperatures [T/spl les/e/sup 2//(10k/sub B/C/sub /spl Sigma//)] and good agreements are observed. The proposed model is implemented in a commercial circuit simulator in order to develop a computer-aided design framework for CMOS-SET hybrid IC designs. A series of SPICE simulations are successfully carried out for different CMOS-SET hybrid circuits in order to reproduce their experimental/Monte Carlo simulated characteristics.     

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production

Interferon-gamma-inducing factor (IGIF, interleukin-18) is a recently described cytokine that shares structural features with the interleukin-1 (IL-1) family of proteins and functional properties with IL-12. Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells. IGIF is synthesized as a biologically inactive precursor molecule (proIGIF). The cellular production of IL-1beta, a cytokine implicated in a variety of inflammatory diseases, requires cleavage of its precursor (proIL-1beta) at an Asp-X site by interleukin-1beta-converting enzyme (ICE, recently termed caspase-1). The Asp-X sequence at the putative processing site in proIGIF suggests that a protease such as caspase-1 might be involved in the maturation of IGIF. Here we demonstrate that caspase-1 processes proIGIF and proIL-1beta with equivalent efficiencies in vitro. A selective caspase-1 inhibitor blocks both lipopolysaccharide-induced IL-1beta and IFN-gamma production from human mononuclear cells. Furthermore, caspase-1-deficient mice are defective in lipopolysaccharide-induced IFN-gamma production. Our results thus implicate caspase-1 in the physiological production of IGIF and demonstrate that it plays a critical role in the regulation of multiple proinflammatory cytokines. Specific caspase-1 inhibitors would provide a new class of anti-inflammatory drugs with multipotent action.     

Renal transplantation in a patient with methylmalonic acidaemia

Renal insufficiency is frequently reported in mutase-deficient methylmalonic acidaemia. We present a case report of a patient with mut- methylmalonic acidaemia who developed chronic tubulointerstitial nephropathy during adolescence. At 24 years of age, she developed end-stage renal failure and underwent renal transplantation. Both plasma and urine methylmalonic acid levels decreased significantly with improved renal function following transplantation. Complications included cyclosporin toxicity and development of diabetes. Renal, metabolic, and clinical status remained improved at 3 years after the kidney transplant.     

Analysis and CMOS implementation of a chaos-based communication system

We describe the design and CMOS implementation of a baseband spread-spectrum communication system using chaotic signals for spreading digital data. The communication system uses a new chaotic modulation scheme called modified differential chaos shift keying (M-DCSK). The M-DCSK scheme and its characteristics are analyzed for single user and multi user applications. The chaotic signals were generated using a simple and robust circuit. The dynamics of this chaos generating circuit are also studied. The spectral properties of the system are investigated and compared with theoretical expectations.     

A multilevel approach toward quadrupling the density of flashmemory

A multilevel scheme is presented that explores the possibility of quadrupling flash EEPROM storage density. Sixteen levels (4 bits/cell) of charge are stored in existing NOR stacked gate devices. A distinction is made between logical threshold voltages (as seen by the sense amplifier) and transistor threshold voltages (as defined by the gate characteristics), and precise programming gives distinct logical threshold voltage distributions, whereas transistor threshold voltage distributions are contained in a small 2.5 V range and kept low so that logical distributions survive a ten-year equivalent data retention bake     

Inertial snake for contour detection in ultrasonography images

Snakes, or active contour models are used extensively for image segmentation in varied fields. However, some major challenges restrict their use in many fields. The authors propose a new inertial snake model, that introduces an inertial effect of the control points into the snake framework. The proposed inertial force along with the first- and second-order continuity forces controls the spline motion through the concavities and also against weak edge forces. This smart force field, added to the inertial energy framework, posses the ability to adaptively reduce its effect near the true edges, so that the energy minimising spline converges into the edges. A greedy snake has been used for computation of the energy minimising spline. The algorithm has been tested on phantoms and ultrasound images as well. It is shown in the results that the proposed algorithm classifies the object from the background class in most of the images perfectly. Ultrasound images of a lower limb artery of an adult woman have been tested with this algorithm, and also extended for motion tracking.     

Protein-Assembled Nanocrystal-Based Vertical Flash Memory Devices with Al<Subscript>2</Subscript>O<Subscript>3</Subscript> Integration

This work presents vertical flash memory devices with protein-assembled PbSe nanocrystals as a floating gate and Al₂O₃ as a control oxide. The advantage of a vertical structure is that it improves cell density. Protein assembly improves uniformity of nanocrystals, which reduces threshold voltage variation among devices. The introduction of Al₂O₃ as a control oxide provided lower voltage/faster operation and hence less power consumption compared with the devices fabricated with SiO₂. The integration of Al₂O₃ appeared to be compatible with the protein assembly approach. In conclusion, Al₂O₃ has the potential to become the high-k control oxide due to its relatively high electron/hole barrier heights, and high permittivity.     

A composite fitting model of discrete handbook data for peripheral end milling

Machining data handbooks are important reference books in the machining industry, as they provide recommended process parameter values for common machining operations. The machining data, although covering a wide range of relevant cutting conditions, are only listed under discrete cutting conditions. Rough interpolation-based calculations are often needed in order to estimate the process parameter values at the desired cutting condition. In this work, a composite fitting model is presented to fit a composite functional curve through the discrete handbook data of recommended cutting speeds and feeds with respect to the cutting condition of radial depth of cut for peripheral end milling. The objective is to establish a functional relationship from the handbook data such that recommended cutting speed and feed can be obtained for any given radial depth of cut. According to the tabulated layout of the machining data, the entire range of the radial depth of cut is divided into three segments having distinctive formulations and trends. Constraints are then imposed to preserve the trends and smoothly connect the adjacent segments. As a possible application of the presented model, a case study of machining a rectangular pocket is provided. Machining time of a potential process plan is readily evaluated based on the cutting speeds and feeds obtained from the composite model.     

Positron lifetime studies and coincidence Doppler broadening spectroscopy of Al–6Mg–<Emphasis Type="Italic">x</Emphasis>Sc (<Emphasis Type="Italic">x</Emphasis> = 0 to 0.6 wt.%) alloy

Positron annihilation spectroscopy (PAS), comprising of both positron lifetime and coincidence Doppler broadening measurements, has been employed for studying the phase decomposition behaviour of scandium doped Al–6Mg alloys. Micro structural and age hardening studies have also been conducted to substantiate the explanation of the results of PAS. Samples with scandium concentration ranging from 0 to 0.6 wt.% have been studied. The measured positron lifetimes of undoped alloy reveal that GP zones are absent in the as-prepared Al–6Mg alloy. The observed positron lifetimes and the results of coincidence Doppler broadening measurements largely stem from the entrap of positrons at the interface between aluminium rich primary dendrites and the magnesium enriched interdendritic eutectic mixture of Mg₅Al₈ (β) and the primary solid solution of aluminium (α). The study also provides evidence of the formation of scandium vacancy complexes in Al–6Mg alloys doped with scandium upto a concentration of 0.2 wt.%. However such complex formation ceases to continue beyond 0.2 wt.% Sc; instead, the formation of fine coherent precipitates of Al₃Sc is recorded in the as prepared alloy containing 0.6 wt.% scandium. The positron annihilation studies coupled with CDBS have also corroborated with the fact that the fine coherent precipitates of Al₃Sc are formed upon annealing the Al–6Mg alloys doped with scandium of concentration 0.2 wt.% and above. Transmission electron microscopic studies have provided good evidence of precipitate formation in annealed Al–6Mg–Sc alloys. Elevated temperature annealing leads to dissociation of the scandium-vacancy complexes, thereby leading to the enhancement of the mobility of magnesium atoms. This has facilitated fresh nucleation and growth of Mg₅Al₈ precipitates in the above alloys at 673 K.     

Sustained release of antibiotic from polyurethane coated implant materials

Implant associated infections are of increasing importance. To minimize the risks of implant-associated infections recent biomedical strategies have led to the modification of the medical device surfaces. The modifications are in the terms of increasing surface biocompatibility and decreasing bacterial adherence, which can be achieved by applying a coating of biocompatible polymer onto the said surfaces. Entrapping anti-infective agents in a polymer matrix provides an approach to kill bacteria and combat the possibility of any residual infection. We have prepared a biodegradable polyester urethane coat for implant materials, which have the property to accommodate antibiotics within itself. These polyurethane coating materials were characterized by FTIR spectroscopy, swelling property in SBF, gravimetric analysis, drug release, and biocompatibility study. Drug release rates, bacterial colonization and morphological features were also evaluated to predict and understand the antimicrobial activity of these delivery systems. Drug release characteristics were investigated and the physico-chemical mechanisms of the delivery were discussed. Results suggest that the polyester urethane can be used as an implant coating material and can be used as a matrix for the sustained delivery of anti-infective agent.